Migraine Builds in Layers.
Most migraine approaches target one mechanism - serotonin, CGRP, muscle tension. But migraines often involve multiple systems at once. When the approach doesn't match the dominant pattern, it underperforms.
These layers can overlap and compound - lowering your migraine threshold over time.
- Hormonal shifts that change your threshold weekly
- Histamine accumulation from diet or environment
- Sleep disruption affecting glymphatic clearance
- Vascular underfill from dehydration or low blood pressure
- Systemic inflammation raising your baseline load
When you address the wrong layer, nothing seems to change. When you identify the layer that's active, your next step becomes clearer.
the Migraine Detective Method approaches migraine this way - layer by layer, instead of trigger by trigger.
If nothing you've tried seems to work at all, read: Nothing Helps My Migraines
If your migraines have become daily, read: Why Do I Get Migraines Every Day?